USO1

Across TCGA patient cohorts, USO1 protein abundance is significantly associated with the RNA expression of many other genes, with 16,905 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible USO1-associated genes across cancer lineages are MDN1, RTTN, and LSM14A. Each is linked with USO1 in more than 5 cancer types. Because this analysis shows association rather than direction, both USO1-to-partner and partner-to-USO1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, USO1 versus MDN1 in HNSC, with a Pearson correlation of -0.29.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USO1→partner) and Y-score (partner→USO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MDN1 →	-0.617	-0.185	.002	.007	3	6
LSCC	RTTN →	-0.636	-0.239	<.001	.004	3	6
HNSC	LSM14A →	-0.645	-0.210	.003	.002	3	6
HNSC	DICER1 →	-0.701	-0.170	.005	.001	3	5
LSCC	FBL →	-0.968	-0.293	<.001	<.001	3	5
LSCC	BLMH →	-0.580	-0.201	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,905 associations by consensus.

USO1 vs MDN1 — HNSC

Explore this scatter interactively →