USO1

Across TCGA cell cohorts, USO1 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible USO1-associated genes across cancer lineages are PATE4, CSH1, and OCSTAMP. Each is linked with USO1 in more than 1 cancer types. Because this analysis shows association rather than direction, both USO1-to-partner and partner-to-USO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PATE4 grouped by USO1-low versus USO1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USO1→partner) and Y-score (partner→USO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PATE4 →	+0.041	+4.095	<.001	.009	3	1
LUNG_NSCLC_LUAD	CSH1 →	+0.037	+3.343	.001	.005	3	1
LUNG_NSCLC_LUAD	OCSTAMP →	+0.013	+3.343	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR1D2 →	+0.013	+4.266	<.001	.004	3	1
LUNG_NSCLC_LUAD	POM121L12 →	+0.015	+4.266	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

PATE4 by USO1 expression — LARGE_INTESTINE

Explore this box plot interactively →