USO1

Across TCGA pan-cancer cohorts, USO1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated USO1 data layer compared with 27 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher USO1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated USO1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and HNSC show a favorable association.

PDAC, HNSC, and CCRCC are the cancer types where USO1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Quartile	II,III,IV	0.724	0.400	.019	12	view →
HNSC	OS	Tertile	All	0.930	0.787	.014	12	view →
CCRCC	OS	Tertile	All	0.769	0.942	.012	10	view →
LUAD	OS	Median	III,IV	0.817	0.335	.004	8	view →
COAD	DFS	Median	IV	1.000	0.605	.043	6	view →
UCEC	DFS	Median	All	0.932	0.785	.027	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

USO1–PDAC (OS)

Open the PDAC breakdown →