USO1

Across TCGA patient cohorts, USO1 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible USO1-associated genes across cancer lineages are C-Raf, Notch1, and FoxM1. Each is linked with USO1 in more than 2 cancer types. Because this analysis shows association rather than direction, both USO1-to-partner and partner-to-USO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by USO1-low versus USO1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (USO1→partner) and Y-score (partner→USO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.167	+2.584	.003	.010	3	3
UCEC	Notch1 →	+0.147	+2.183	.009	.033	3	2
UCEC	FoxM1 →	+0.252	+2.415	.015	.003	3	1
UCEC	MEK1 →	+0.292	+2.321	.047	.034	3	1
UCEC	PDCD4 →	-0.430	-1.906	.023	.016	3	1
UCEC	VHL →	-1.061	-3.000	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

C-Raf by USO1 expression — UCEC

Explore this box plot interactively →