uridine phosphorylase 1Genealiases: UDRPASE · UP · UPASE · UPP
Q-omics provides the consensus-scored UPP1 profile across patient tissues and cancer cell-line models. UPP1 expression is associated with patient survival in 26 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, UPP1 is differentially expressed in 14, with the highest sampling consensus in THCA. Additionally, UPP1 protein abundance shows 26,778 significant protein co-abundance associations, with the highest sampling consensus in GBM. Together, these results highlight KIRC, THCA, and GBM as cancer lineages where UPP1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for UPP1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes UPP1 survival associations across molecular data types. UPP1 RNA expression shows survival associations in the most cancer types (26), followed by mutation status (4) and mass-spec protein abundance (8). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible UPP1 RNA expression–survival associations across cancer types. High UPP1 expression shows unfavorable associations in KIRC, UVM, MESO, ACC, LGG and LIHC. The KIRC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for UPP1 RNA expression.
This table summarizes UPP1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 14, while mass-spec protein shows differences in 6. The strongest signals are observed in THCA for RNA and COAD for protein.
This table ranks reproducible tumor–normal expression differences for UPP1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. UPP1 shows higher tumor expression in THCA, KIRP, KIRC, BLCA, HNSC and KICH. The THCA box plot shows higher UPP1 RNA expression in tumor versus normal tissue (log2 FC = +2.444, t-test p < 0.001).
This table shows molecular features associated with UPP1 in patient tissues and cancer cell lines. In patient samples, UPP1 shows the broadest associations at the RNA and protein expression levels, with GBM recurring as the lineage with the largest associated feature set. In cancer cell lines, UPP1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in UPPER_AERODIGESTIVE_TRACT, while CRISPR and shRNA rows add functional-dependency signals in SKIN and BONE.
