Across TCGA pan-cancer cohorts, UPP1 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated UPP1 data layer compared with 26 for mass-spec protein and 8 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher UPP1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated UPP1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

BRCA, KICH, and LUAD are the cancer types where UPP1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Median	All	0.105	0.579	<.001	24	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
LUAD	DFS	Median	II,III,IV	0.098	0.682	<.001	6	view →
UCEC	DFS	Median	All	1.000	0.636	.038	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: UPP1 tumor-vs-normal RNA expression · all UPP1 data types