Across TCGA patient cohorts, UPP1 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UPP1-associated genes across cancer lineages are eEF2, EGFR_pY1068, and ERK2. Each is linked with UPP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both UPP1-to-partner and partner-to-UPP1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UPP1→partner) and Y-score (partner→UPP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.514	+2.999	.002	.035	3	1
UCEC	EGFR_pY1068 →	-0.378	-2.459	.001	.020	3	1
UCEC	ERK2 →	+0.223	+2.459	.016	.020	3	1
UCEC	Fibronectin →	-0.408	-3.160	.010	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.215	-2.446	.008	.020	3	1
UCEC	Ku80 →	+0.300	+2.472	.008	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

Exploration

UPP1 survival (RNA) · tumor vs normal (RNA) · all UPP1 data types