Across TCGA patient cohorts, UPP1 mutation is significantly associated with the RNA expression of many other genes, with 321 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UPP1-associated genes across cancer lineages are MIR5787, RN7SL700P, and RN7SKP65. Each is linked with UPP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both UPP1-to-partner and partner-to-UPP1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UPP1→partner) and Y-score (partner→UPP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR5787 →	+0.661	+4.513	<.001	.009	3	2
COAD	RN7SL700P →	+0.333	+6.251	.004	.001	3	2
HNSC	RN7SKP65 →	+0.091	+3.864	.004	.004	3	2
HNSC	RNU7-194P →	+0.297	+4.936	<.001	.003	3	2
BRCA	POTEB3 →	+0.024	+4.995	.003	.009	3	1
UCEC	CCL5 →	+1.218	+3.338	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 321 associations by consensus.

Exploration

UPP1 survival (RNA) · tumor vs normal (RNA) · all UPP1 data types