UDP glucuronosyltransferase family 2 member B4Genealiases: HLUG25 · UDPGT2B4 · UDPGTH1 · UDPGTh-1 · UGT2B11
Q-omics provides the consensus-scored UGT2B4 profile across patient tissues and cancer cell-line models. UGT2B4 expression is associated with patient survival in 23 of 34 cancer types, with the highest sampling consensus in OV. Among the 18 cancer types available for tumor–normal comparison, UGT2B4 is differentially expressed in 8, with the highest sampling consensus in LUAD. Additionally, UGT2B4 RNA expression shows 6,827 significant gene co-expression associations, with the highest sampling consensus in TGCT. Together, these results highlight OV, LUAD, and TGCT as cancer lineages where UGT2B4 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for UGT2B4 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes UGT2B4 survival associations across molecular data types. UGT2B4 RNA expression shows survival associations in the most cancer types (23), followed by mutation status (8) and mass-spec protein abundance (1). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible UGT2B4 RNA expression–survival associations across cancer types. High UGT2B4 expression shows unfavorable associations in OV, KICH, LUSC and KIRP, but favorable associations in UCS and READ. The OV Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify OV as the clearest survival context for UGT2B4 RNA expression.
This table summarizes UGT2B4 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 8, while mass-spec protein shows differences in 2. The strongest signals are observed in LUSC for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for UGT2B4. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. UGT2B4 shows lower tumor expression in LUAD, LUSC, CHOL and KIRC and higher tumor expression in READ and PRAD. The LUAD box plot shows higher UGT2B4 RNA expression in normal versus tumor tissue (log2 FC = −1.289, t-test p < 0.001).
This table shows molecular features associated with UGT2B4 in patient tissues and cancer cell lines. In patient samples, UGT2B4 shows the broadest associations at the RNA and protein expression levels, with TGCT recurring as the lineage with the largest associated feature set. In cancer cell lines, UGT2B4 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in PANCREAS, while CRISPR and shRNA rows add functional-dependency signals in BREAST and LARGE_INTESTINE.
