UGT2B4

Across TCGA cell cohorts, UGT2B4 mutation is significantly associated with the RNA expression of many other genes, with 64 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible UGT2B4-associated genes across cancer lineages are MTARC2, RAB8A, and ZFAND4. Each is linked with UGT2B4 in more than 1 cancer types. Because this analysis shows association rather than direction, both UGT2B4-to-partner and partner-to-UGT2B4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTARC2 grouped by UGT2B4-low versus UGT2B4-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UGT2B4→partner) and Y-score (partner→UGT2B4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	MTARC2 →	+1.403	+3.364	<.001	.002	3	2
SKIN	RAB8A →	+0.458	+2.472	.007	.008	3	2
SKIN	ZFAND4 →	+0.599	+3.451	.009	.002	3	2
SKIN	PALD1 →	+0.725	+3.364	<.001	.002	3	1
SKIN	VGF →	-2.765	-3.278	.003	.006	3	1
SKIN	SLC7A10 →	+0.139	+2.247	.002	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 64 associations by consensus.

MTARC2 by UGT2B4 expression — SKIN

Explore this box plot interactively →