UGT2B4

Across TCGA pan-cancer cohorts, UGT2B4 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated UGT2B4 data layer compared with 8 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher UGT2B4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated UGT2B4 expression acts as an unfavorable survival marker, although some lineages such as UCS and READ show a favorable association.

OV, UCS, and KICH are the cancer types where UGT2B4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	OS	Quartile	All	0.734	0.874	<.001	96	view →
UCS	DFS	Median	II,III,IV	0.539	0.179	.001	68	view →
KICH	DFS	Quartile	All	0.622	1.000	.001	67	view →
LUSC	DFS	Tertile	All	0.291	0.493	<.001	66	view →
KIRP	DFS	Quartile	All	0.740	0.914	<.001	34	view →
READ	DFS	Tertile	II,III,IV	0.935	0.447	.011	29	view →
STAD	DFS	Tertile	II,III,IV	0.222	0.542	.015	23	view →
THYM	DFS	Tertile	II,III,IV	0.440	0.796	.006	18	view →
SCLC	DFS	Quartile	II,III,IV	0.274	0.830	.006	18	view →
COAD	OS	Median	III,IV	0.860	0.713	.021	14	view →
ACC	DFS	Quartile	All	0.902	0.497	.011	10	view →
SARC	DFS	Median	All	0.433	0.606	.014	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

UGT2B4–OV (OS)

Open the OV breakdown →