UGT2B4

Across TCGA patient cohorts, UGT2B4 mutation is significantly associated with the RNA expression of many other genes, with 3,936 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UGT2B4-associated genes across cancer lineages are UQCRH, H2AZ1, and GAS2L1. Each is linked with UGT2B4 in more than 3 cancer types. Because this analysis shows association rather than direction, both UGT2B4-to-partner and partner-to-UGT2B4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UQCRH grouped by UGT2B4-low versus UGT2B4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UGT2B4→partner) and Y-score (partner→UGT2B4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	UQCRH →	+0.653	+2.839	.008	.001	3	4
UCEC	H2AZ1 →	+0.566	+2.091	<.001	<.001	3	4
UCEC	GAS2L1 →	+0.412	+1.523	.002	.008	3	3
UCEC	SULT1C4 →	-0.710	-1.523	.003	.008	3	3
UCEC	RNU6-451P →	+0.305	+2.024	<.001	.002	3	3
HNSC	BNIP3L →	+0.594	+3.619	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,936 associations by consensus.

UQCRH by UGT2B4 expression — UCEC

Explore this box plot interactively →