UGT2B4

Across TCGA patient cohorts, UGT2B4 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UGT2B4-associated genes across cancer lineages are Cyclin-B1, Beclin, and PREX1. Each is linked with UGT2B4 in more than 3 cancer types. Because this analysis shows association rather than direction, both UGT2B4-to-partner and partner-to-UGT2B4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by UGT2B4-low versus UGT2B4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UGT2B4→partner) and Y-score (partner→UGT2B4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.530	+2.584	.005	.010	3	4
LUAD	Beclin →	-0.115	-2.987	.049	.035	3	3
SKCM	PREX1 →	-0.197	-1.736	.026	.005	3	3
UCEC	ACC_pS79 →	+0.280	+1.495	.017	.034	3	2
UCEC	ACC1 →	+0.308	+1.247	.013	.045	3	2
UCEC	Ku80 →	+0.298	+1.820	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

Cyclin-B1 by UGT2B4 expression — UCEC

Explore this box plot interactively →