UDP glucuronosyltransferase family 1 member A5Genealiases: UDPGT · UDPGT 1-5 · UGT1E
Q-omics provides the consensus-scored UGT1A5 profile across patient tissues and cancer cell-line models. UGT1A5 expression is associated with patient survival in 13 of 34 cancer types, with the highest sampling consensus in UCS. Among the 18 cancer types available for tumor–normal comparison, UGT1A5 is differentially expressed in 7, with the highest sampling consensus in COAD. Additionally, UGT1A5 RNA expression shows 11,800 significant protein co-abundance associations, with the highest sampling consensus in LSCC. Together, these results highlight UCS, COAD, and LSCC as cancer lineages where UGT1A5 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for UGT1A5 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes UGT1A5 survival associations across molecular data types. UGT1A5 RNA expression shows survival associations in the most cancer types (13), followed by mutation status (3). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible UGT1A5 RNA expression–survival associations across cancer types. High UGT1A5 expression shows unfavorable associations in UCS, KIRP, LIHC and HNSC, but favorable associations in LAML and KIRC. The UCS Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .009). Together, the overview and detailed table identify UCS as the clearest survival context for UGT1A5 RNA expression.
This table summarizes UGT1A5 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 7. The strongest signals are observed in COAD for RNA.
This table ranks reproducible tumor–normal expression differences for UGT1A5. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. UGT1A5 shows lower tumor expression in COAD and higher tumor expression in KIRC, KIRP, PAAD, LUSC and LIHC. The COAD box plot shows higher UGT1A5 RNA expression in normal versus tumor tissue (log2 FC = −0.094, t-test p = .001).
This table shows molecular features associated with UGT1A5 in patient tissues and cancer cell lines. In patient samples, UGT1A5 shows the broadest associations at the RNA and protein expression levels, with LSCC recurring as the lineage with the largest associated feature set. In cancer cell lines, UGT1A5 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LUNG_NSCLC_LUAD, while CRISPR and shRNA rows add functional-dependency signals in CNS and BONE.
