UGT1A5

Across TCGA patient cohorts, UGT1A5 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,800 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible UGT1A5-associated proteins across cancer lineages are AKR1C3, UGT1A6, and AKR1C1. Each is linked with UGT1A5 in more than 5 cancer types. Because this analysis shows association rather than direction, both UGT1A5-to-partner and partner-to-UGT1A5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, UGT1A5 versus AKR1C3 in LSCC, with a Pearson correlation of 0.62.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (UGT1A5→partner) and Y-score (partner→UGT1A5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	AKR1C3 →	+1.711	+2.118	<.001	<.001	3	6
LSCC	UGT1A6 →	+1.473	+2.267	<.001	<.001	3	4
LSCC	AKR1C1 →	+2.167	+2.338	<.001	<.001	3	4
LSCC	AKR1C3_S129 →	+1.719	+1.704	<.001	<.001	3	4
HNSC	KRT19 →	+0.859	+1.082	<.001	<.001	3	3
LSCC	MTX3 →	+0.367	+1.719	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,800 associations by consensus.

UGT1A5 vs AKR1C3 — LSCC

Explore this scatter interactively →