UGT1A5

Across TCGA pan-cancer cohorts, UGT1A5 RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated UGT1A5 data layer compared with 3 for mutation status.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher UGT1A5 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated UGT1A5 expression acts as an unfavorable survival marker, although some lineages such as LAML and KIRC show a favorable association.

UCS, KIRP, and LIHC are the cancer types where UGT1A5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	OS	Tertile	All	0.135	0.687	.009	72	view →
KIRP	OS	Quartile	All	0.633	0.933	<.001	60	view →
LIHC	OS	Median	All	0.622	0.749	.002	60	view →
LAML	DFS	Tertile	All	0.892	0.329	.003	36	view →
HNSC	OS	Tertile	All	0.406	0.644	.004	36	view →
KIRC	DFS	Tertile	II,III,IV	0.883	0.738	.006	32	view →
LGG	DFS	Tertile	All	0.221	0.848	<.001	24	view →
COAD	OS	Tertile	IV	0.098	0.676	.001	18	view →
PRAD	OS	Tertile	All	0.981	0.995	.010	12	view →
LUSC	OS	Median	II,III,IV	0.797	0.667	.010	11	view →
PAAD	OS	Tertile	All	0.448	0.636	.014	9	view →
ESCA	OS	Quartile	IV	0.309	0.713	.038	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

UGT1A5–UCS (OS)

Open the UCS breakdown →