UGT1A5

Across TCGA patient cohorts, UGT1A5 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,852 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible UGT1A5-associated GO terms across cancer lineages are Response to L-phenylalanine derivative, Flavone metabolic process, and Regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis. Each is linked with UGT1A5 in more than 9 cancer types. Because this analysis shows association rather than direction, both UGT1A5-to-partner and partner-to-UGT1A5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to L-phenylalanine derivative grouped by UGT1A5-low versus UGT1A5-high in KIRP.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (UGT1A5→partner) and Y-score (partner→UGT1A5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIRP	Response to L-phenylalanine derivative →	+0.065	+0.034	<.001	<.001	3	10
LUSC	Flavone metabolic process →	+0.745	+0.043	<.001	<.001	3	10
LUSC	Regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis →	+0.040	+0.060	<.001	<.001	3	9
STAD	Polyprenol metabolic process →	+0.062	+0.077	<.001	<.001	3	8
LUSC	Glycoside metabolic process →	+0.082	+0.080	<.001	<.001	3	8
ESCA	Rac protein signal transduction →	+0.063	+0.138	<.001	<.001	2	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,852 associations by consensus.

Response to L-phenylalanine derivative by UGT1A5 expression — KIRP

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