UGT1A5

Across TCGA cell cohorts, UGT1A5 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible UGT1A5-associated genes across cancer lineages are WFDC6, OR5B21, and OR6Q1. Each is linked with UGT1A5 in more than 1 cancer types. Because this analysis shows association rather than direction, both UGT1A5-to-partner and partner-to-UGT1A5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, WFDC6 grouped by UGT1A5-low versus UGT1A5-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UGT1A5→partner) and Y-score (partner→UGT1A5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	WFDC6 →	+0.057	+5.472	<.001	<.001	3	1
LARGE_INTESTINE	OR5B21 →	+0.241	+4.977	<.001	.007	3	1
LARGE_INTESTINE	OR6Q1 →	+0.030	+6.022	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

WFDC6 by UGT1A5 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →