UGT1A5

Across TCGA patient cohorts, UGT1A5 mutation is significantly associated with the RNA expression of many other genes, with 801 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UGT1A5-associated genes across cancer lineages are RNU6-1234P, RNU6-732P, and CENPP. Each is linked with UGT1A5 in more than 2 cancer types. Because this analysis shows association rather than direction, both UGT1A5-to-partner and partner-to-UGT1A5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1234P grouped by UGT1A5-low versus UGT1A5-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UGT1A5→partner) and Y-score (partner→UGT1A5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-1234P →	+0.345	+4.962	.001	.003	3	3
SKCM	RNU6-732P →	+0.195	+4.315	<.001	.005	3	2
UCEC	CENPP →	+0.365	+3.475	<.001	.002	3	2
UCEC	TMEM116 →	+0.477	+3.395	<.001	.004	3	2
UCEC	RNA5SP418 →	+0.837	+2.278	<.001	.005	3	2
UCEC	RNA5SP415 →	+0.680	+2.488	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 801 associations by consensus.

RNU6-1234P by UGT1A5 expression — COAD

Explore this box plot interactively →