UGT1A5

Across TCGA patient cohorts, UGT1A5 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UGT1A5-associated genes across cancer lineages are p27_pT198, S6_pS235_S236, and VHL. Each is linked with UGT1A5 in more than 1 cancer types. Because this analysis shows association rather than direction, both UGT1A5-to-partner and partner-to-UGT1A5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p27_pT198 grouped by UGT1A5-low versus UGT1A5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UGT1A5→partner) and Y-score (partner→UGT1A5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p27_pT198 →	+0.116	+2.700	.016	.006	3	2
UCEC	S6_pS235_S236 →	+0.603	+3.584	.001	.002	3	2
UCEC	VHL →	-1.045	-2.321	<.001	.034	3	2
UCEC	c-Met_pY1235 →	+0.075	+2.331	.025	.019	3	2
UCEC	Cyclin-E2 →	+0.172	+2.700	.023	.006	3	2
UCEC	JNK_pT183_Y185 →	-0.167	-1.986	.027	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

p27_pT198 by UGT1A5 expression — UCEC

Explore this box plot interactively →