UGT1A5

Across TCGA pan-cancer cohorts, UGT1A5 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated UGT1A5 data layer compared with 13 for mass-spec protein.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher UGT1A5 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated UGT1A5 expression acts as an unfavorable survival marker.

STAD, CESC, and SKCM are the cancer types where UGT1A5 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	OS	Median	III,IV	0.003	0.633	<.001	33	view →
CESC	DFS	Median	II,III,IV	0.140	0.785	<.001	18	view →
SKCM	OS	Median	All	0.693	0.882	.017	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

UGT1A5–STAD (OS)

Open the STAD breakdown →