Q-omics provides the consensus-scored UFC1 profile across patient tissues and cancer cell-line models. UFC1 expression is associated with patient survival in 19 of 34 cancer types, with the highest sampling consensus in UVM. Among the 18 cancer types available for tumor–normal comparison, UFC1 is differentially expressed in 10, with the highest sampling consensus in KIRC. Additionally, UFC1 protein abundance shows 21,185 significant protein co-abundance associations, with the highest sampling consensus in PDAC. Together, these results highlight UVM, KIRC, and PDAC as cancer lineages where UFC1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for UFC1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes UFC1 survival associations across molecular data types. UFC1 RNA expression shows survival associations in the most cancer types (19), followed by mutation status (2) and mass-spec protein abundance (5). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible UFC1 RNA expression–survival associations across cancer types. High UFC1 expression shows unfavorable associations in UVM, ACC, LIHC, KIRP, KICH and ESCA. The UVM Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify UVM as the clearest survival context for UFC1 RNA expression.
This table summarizes UFC1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 10, while mass-spec protein shows differences in 5. The strongest signals are observed in KIRC for RNA and LUAD for protein.
This table ranks reproducible tumor–normal expression differences for UFC1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. UFC1 shows lower tumor expression in KICH and higher tumor expression in KIRC, BLCA, LIHC, BRCA and LUAD. The KIRC box plot shows higher UFC1 RNA expression in tumor versus normal tissue (log2 FC = +0.605, t-test p < 0.001).
This table shows molecular features associated with UFC1 in patient tissues and cancer cell lines. In patient samples, UFC1 shows the broadest associations at the RNA and protein expression levels, with PDAC recurring as the lineage with the largest associated feature set. In cancer cell lines, UFC1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in BLOOD_Leukemia, while CRISPR and shRNA rows add functional-dependency signals in PANCREAS and UPPER_AERODIGESTIVE_TRACT.
