UFC1

Across TCGA cell cohorts, UFC1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,730 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible UFC1-associated GO terms across cancer lineages are Positive regulation of necroptotic process, Negative regulation of CD8-positive, alpha-beta T cell differentiation, and Sugar mediated signaling pathway. Each is linked with UFC1 in more than 9 cancer types. Because this analysis shows association rather than direction, both UFC1-to-partner and partner-to-UFC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of necroptotic process grouped by UFC1-low versus UFC1-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (UFC1→partner) and Y-score (partner→UFC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Positive regulation of necroptotic process →	+0.142	+0.616	.006	.001	3	10
LUNG_NSCLC_LUSC	Negative regulation of CD8-positive, alpha-beta T cell differentiation →	+0.186	+0.713	.005	.002	2	10
URINARY_TRACT	Sugar mediated signaling pathway →	+0.233	+1.088	.004	.001	3	9
URINARY_TRACT	Glucose mediated signaling pathway →	+0.233	+1.088	.004	.001	3	9
URINARY_TRACT	Hexose mediated signaling →	+0.233	+1.088	.004	.001	3	9
UPPER_AERODIGESTIVE_TRACT	Skin development →	-0.144	-1.089	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,730 associations by consensus.

Positive regulation of necroptotic process by UFC1 expression — LIVER

Explore this box plot interactively →