UFC1

Across TCGA pan-cancer cohorts, UFC1 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated UFC1 data layer compared with 2 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher UFC1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated UFC1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and MESO show a favorable association.

UVM, ACC, and LIHC are the cancer types where UFC1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.454	0.812	<.001	109	view →
ACC	DFS	Median	All	0.236	0.643	<.001	89	view →
LIHC	OS	Median	All	0.716	0.835	<.001	78	view →
KIRP	DFS	Tertile	All	0.868	0.988	.001	57	view →
KICH	OS	Tertile	All	0.727	1.000	.005	38	view →
ESCA	DFS	Median	III,IV	0.326	0.546	.017	30	view →
STAD	OS	Quartile	II,III,IV	0.413	0.793	.015	21	view →
SCLC	DFS	Median	IV	0.137	0.559	.008	16	view →
KIRC	DFS	Median	IV	0.612	0.307	.023	14	view →
CESC	DFS	Quartile	All	0.641	0.834	.006	14	view →
CHOL	DFS	Quartile	All	0.122	0.819	.002	14	view →
HNSC	OS	Median	All	0.273	0.512	.006	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

UFC1–UVM (OS)

Open the UVM breakdown →