UFC1

Across TCGA patient cohorts, UFC1 mutation is significantly associated with the RNA expression of many other genes, with 130 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UFC1-associated genes across cancer lineages are DEFB135, SLC30A6P1, and RN7SL466P. Each is linked with UFC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both UFC1-to-partner and partner-to-UFC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFB135 grouped by UFC1-low versus UFC1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UFC1→partner) and Y-score (partner→UFC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	DEFB135 →	+0.203	+6.003	<.001	.002	3	2
COAD	SLC30A6P1 →	+0.434	+5.516	<.001	.004	3	2
COAD	RN7SL466P →	+0.313	+7.142	.009	<.001	3	2
COAD	RNU6-927P →	+0.921	+5.017	<.001	.009	3	2
COAD	RNU6-313P →	+0.399	+5.145	<.001	.007	3	2
UCEC	ZC3H18 →	+0.579	+3.491	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 130 associations by consensus.

DEFB135 by UFC1 expression — COAD

Explore this box plot interactively →