UFC1

Across TCGA patient cohorts, UFC1 mutation is significantly associated with the total protein of many other genes, with 2 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UFC1-associated genes across cancer lineages are p27_pT157 and Annexin-1. Each is linked with UFC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both UFC1-to-partner and partner-to-UFC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p27_pT157 grouped by UFC1-low versus UFC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UFC1→partner) and Y-score (partner→UFC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p27_pT157 →	-0.080	-2.986	.008	.035	3	1
UCEC	Annexin-1 →	+0.846	+3.321	.002	.010	1	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

p27_pT157 by UFC1 expression — UCEC

Explore this box plot interactively →