tyrosinase related protein 1Genealiases: CAS2 · CATB · GP75 · OCA3 · TRP · TRP1
Q-omics provides the consensus-scored TYRP1 profile across patient tissues and cancer cell-line models. TYRP1 expression is associated with patient survival in 20 of 34 cancer types, with the highest sampling consensus in KICH. Among the 18 cancer types available for tumor–normal comparison, TYRP1 is differentially expressed in 14, with the highest sampling consensus in KIRC. Additionally, TYRP1 RNA expression shows 13,623 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight KICH, KIRC, and THYM as cancer lineages where TYRP1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for TYRP1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes TYRP1 survival associations across molecular data types. TYRP1 RNA expression shows survival associations in the most cancer types (20), followed by mutation status (5) and mass-spec protein abundance (1). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible TYRP1 RNA expression–survival associations across cancer types. High TYRP1 expression shows unfavorable associations in KICH, KIRP, KIRC, CESC, SKCM and THCA. The KICH Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KICH as the clearest survival context for TYRP1 RNA expression.
This table summarizes TYRP1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 14, while mass-spec protein shows differences in 1. The strongest signals are observed in KIRC for RNA and HNSC for protein.
This table ranks reproducible tumor–normal expression differences for TYRP1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. TYRP1 shows lower tumor expression in KIRC, KICH, KIRP, LUAD and LUSC and higher tumor expression in STAD. The KIRC box plot shows higher TYRP1 RNA expression in normal versus tumor tissue (log2 FC = −3.608, t-test p < 0.001).
This table shows molecular features associated with TYRP1 in patient tissues and cancer cell lines. In patient samples, TYRP1 shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set. In cancer cell lines, TYRP1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in KIDNEY, while CRISPR and shRNA rows add functional-dependency signals in LUNG_NSCLC_LUAD and SKIN.
