TYRP1

Across TCGA patient cohorts, TYRP1 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TYRP1-associated genes across cancer lineages are MEK1, Annexin-1, and Src_pY527. Each is linked with TYRP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TYRP1-to-partner and partner-to-TYRP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by TYRP1-low versus TYRP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TYRP1→partner) and Y-score (partner→TYRP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.389	+2.502	.002	.001	3	2
UCEC	Annexin-1 →	+0.662	+2.926	<.001	<.001	3	2
UCEC	Src_pY527 →	-0.375	-2.105	.012	.017	3	2
UCEC	53BP1 →	+0.278	+2.459	.019	.018	3	2
UCEC	Dvl3 →	+0.158	+1.874	.012	.049	3	2
UCEC	14-3-3_beta →	-0.075	-1.673	.030	.040	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

MEK1 by TYRP1 expression — UCEC

Explore this box plot interactively →