TYRP1

Across TCGA pan-cancer cohorts, TYRP1 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated TYRP1 data layer compared with 5 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher TYRP1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TYRP1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and LIHC show a favorable association.

KICH, KIRP, and KIRC are the cancer types where TYRP1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Quartile	II,III,IV	0.490	1.000	<.001	106	view →
KIRP	OS	Tertile	III,IV	0.363	0.799	<.001	96	view →
KIRC	DFS	Tertile	All	0.819	0.933	.001	94	view →
CESC	DFS	Quartile	All	0.718	0.895	<.001	86	view →
SKCM	OS	Tertile	All	0.270	0.431	<.001	46	view →
THCA	OS	Quartile	All	0.922	0.994	.001	33	view →
LUAD	OS	Median	All	0.733	0.635	.007	27	view →
HNSC	DFS	Quartile	All	0.523	0.677	.003	26	view →
BLCA	OS	Quartile	All	0.663	0.817	.008	25	view →
LIHC	DFS	Median	III,IV	0.362	0.164	.019	24	view →
OV	DFS	Median	III,IV	0.120	0.189	.010	18	view →
ESCA	DFS	Median	IV	0.205	0.634	.006	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

TYRP1–KICH (DFS)

Open the KICH breakdown →