TYRP1

Across TCGA pan-cancer cohorts, TYRP1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of TYRP1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TYRP1 RNA is repressed in tumor relative to normal tissue. In most cancer types TYRP1 is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

KIRC, KICH, and KIRP are the cancer types where TYRP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TYRP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	IV	−3.608	<.001	12	view →
KICH	Female	II,III,IV	−4.074	<.001	11	view →
KIRP	Female	II,III,IV	−4.016	<.001	11	view →
LUAD	Male	III,IV	−2.115	<.001	9	view →
LUSC	All	III,IV	−1.768	<.001	9	view →
STAD	All	All	+0.880	<.001	7	view →
BRCA	Female	II,III,IV	+0.510	<.001	6	view →
COAD	All	All	−0.381	.018	4	view →
HNSC	All	All	−0.653	.039	3	view →
LIHC	All	All	+0.399	<.001	3	view →
READ	All	All	−0.683	.020	2	view →
CHOL	All	All	+0.528	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

TYRP1–KIRC

Open the KIRC breakdown →