TYRP1

Across TCGA cell cohorts, TYRP1 mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TYRP1-associated genes across cancer lineages are PRB1, F9, and WFDC12. Each is linked with TYRP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TYRP1-to-partner and partner-to-TYRP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRB1 grouped by TYRP1-low versus TYRP1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TYRP1→partner) and Y-score (partner→TYRP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PRB1 →	+0.039	+3.523	<.001	.008	3	1
BLOOD_Leukemia	F9 →	+0.011	+4.384	<.001	.006	3	1
BLOOD_Leukemia	WFDC12 →	+0.198	+3.874	<.001	.005	3	1
BLOOD_Leukemia	DEFB4A →	+0.129	+5.684	<.001	<.001	3	1
BLOOD_Leukemia	DELEC1 →	+0.783	+3.855	<.001	.007	3	1
BLOOD_Leukemia	DIRC1 →	+0.029	+4.384	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

PRB1 by TYRP1 expression — LUNG_SCLC

Explore this box plot interactively →