transmembrane protein 38AGenealiases: TRIC-A · TRICA
Q-omics provides the consensus-scored TMEM38A profile across patient tissues and cancer cell-line models. TMEM38A expression is associated with patient survival in 20 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, TMEM38A is differentially expressed in 11, with the highest sampling consensus in KIRC. Additionally, TMEM38A RNA expression shows 18,660 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight KIRC, and ACC as cancer lineages where TMEM38A shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for TMEM38A — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes TMEM38A survival associations across molecular data types. TMEM38A RNA expression shows survival associations in the most cancer types (20), followed by mutation status (4) and mass-spec protein abundance (2). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible TMEM38A RNA expression–survival associations across cancer types. High TMEM38A expression shows unfavorable associations in UCEC and ACC, but favorable associations in KIRC, LUAD, UCS and SCLC. The KIRC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for TMEM38A RNA expression.
This table summarizes TMEM38A tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 11, while mass-spec protein shows differences in 3. The strongest signals are observed in KIRC for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for TMEM38A. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. TMEM38A shows lower tumor expression in KIRC, THCA and HNSC and higher tumor expression in KICH, LIHC and UCEC. The KIRC box plot shows higher TMEM38A RNA expression in normal versus tumor tissue (log2 FC = −1.775, t-test p < 0.001).
This table shows molecular features associated with TMEM38A in patient tissues and cancer cell lines. In patient samples, TMEM38A shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set. In cancer cell lines, TMEM38A RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LUNG_SCLC, while CRISPR and shRNA rows add functional-dependency signals in BLOOD_Lymphoma and LARGE_INTESTINE.
