TMEM38A

Across TCGA cell cohorts, TMEM38A RNA expression is significantly associated with the go_rna of many other GO terms, with 5,187 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible TMEM38A-associated GO terms across cancer lineages are Purine ribonucleoside triphosphate metabolic process, Cellular response to amino acid starvation, and Negative regulation of syncytium formation by plasma membrane fusion. Each is linked with TMEM38A in more than 7 cancer types. Because this analysis shows association rather than direction, both TMEM38A-to-partner and partner-to-TMEM38A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Purine ribonucleoside triphosphate metabolic process grouped by TMEM38A-low versus TMEM38A-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM38A→partner) and Y-score (partner→TMEM38A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Purine ribonucleoside triphosphate metabolic process →	+0.086	+1.677	<.001	<.001	3	8
LARGE_INTESTINE	Cellular response to amino acid starvation →	+0.041	+0.690	<.001	<.001	3	8
OVARY	Negative regulation of syncytium formation by plasma membrane fusion →	+0.121	+1.463	<.001	<.001	3	8
BLOOD_Lymphoma	Negative regulation of respiratory burst involved in inflammatory response →	+0.114	+1.442	<.001	<.001	3	8
BLOOD_Lymphoma	Negative regulation of respiratory burst →	+0.114	+1.442	<.001	<.001	3	8
LUNG_SCLC	Regulation of dense core granule exocytosis →	+0.876	+0.860	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,187 associations by consensus.

Purine ribonucleoside triphosphate metabolic process by TMEM38A expression — OVARY

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