TMEM38A

Across TCGA pan-cancer cohorts, TMEM38A RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated TMEM38A data layer compared with 4 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher TMEM38A RNA is associated with better overall survival. In most high-consensus cancer types, elevated TMEM38A expression acts as an unfavorable survival marker, although some lineages such as KIRC and LUAD show a favorable association.

KIRC, LUAD, and UCEC are the cancer types where TMEM38A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.701	0.563	<.001	116	view →
LUAD	DFS	Quartile	All	0.839	0.621	.001	39	view →
UCEC	OS	Median	All	0.895	0.957	.002	28	view →
ACC	DFS	Median	All	0.526	0.782	.004	25	view →
UCS	DFS	Quartile	II,III,IV	0.690	0.138	.002	16	view →
SCLC	OS	Median	II,III,IV	0.978	0.443	.012	13	view →
ESCA	DFS	Tertile	IV	0.226	0.704	.024	12	view →
KIRP	DFS	Tertile	IV	0.370	0.700	.010	12	view →
THYM	OS	Tertile	All	0.744	1.000	.009	11	view →
MESO	OS	Quartile	All	0.509	0.258	.007	10	view →
BLCA	DFS	Median	IV	0.563	0.371	.013	10	view →
THCA	OS	Tertile	All	0.963	1.000	.024	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

TMEM38A–KIRC (OS)

Open the KIRC breakdown →