TMEM38A

Across TCGA patient cohorts, TMEM38A mutation is significantly associated with the RNA expression of many other genes, with 133 significant associations in total. BLCA shows the largest number of these associations.

The most reproducible TMEM38A-associated genes across cancer lineages are MIR3137, MIR6792, and SLIT1-AS1. Each is linked with TMEM38A in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM38A-to-partner and partner-to-TMEM38A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3137 grouped by TMEM38A-low versus TMEM38A-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM38A→partner) and Y-score (partner→TMEM38A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MIR3137 →	+0.389	+3.565	<.001	.007	3	2
LUSC	MIR6792 →	+0.475	+4.211	<.001	.002	3	2
CESC	SLIT1-AS1 →	+0.075	+5.418	<.001	.005	3	2
UCEC	RN7SKP104 →	+0.086	+4.049	<.001	.008	3	2
UCEC	RNA5SP86 →	+0.515	+3.077	<.001	.009	3	2
SKCM	PPIAP80 →	+0.148	+3.126	.006	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 133 associations by consensus.

MIR3137 by TMEM38A expression — LUSC

Explore this box plot interactively →