TMEM38A

Across TCGA cell cohorts, TMEM38A mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TMEM38A-associated genes across cancer lineages are ELOA3DP, OR13G1, and PHOX2B. Each is linked with TMEM38A in more than 1 cancer types. Because this analysis shows association rather than direction, both TMEM38A-to-partner and partner-to-TMEM38A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ELOA3DP grouped by TMEM38A-low versus TMEM38A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TMEM38A→partner) and Y-score (partner→TMEM38A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ELOA3DP →	+0.039	+4.273	<.001	.006	3	1
LARGE_INTESTINE	OR13G1 →	+0.024	+4.415	<.001	.007	3	1
BLOOD_Leukemia	PHOX2B →	+0.020	+4.365	<.001	.002	3	1
BLOOD_Leukemia	LCE2A →	+0.042	+4.384	<.001	.006	3	1
BLOOD_Leukemia	TEX43 →	+0.084	+4.384	<.001	.006	3	1
BLOOD_Leukemia	CCT8L2 →	+0.015	+3.874	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

ELOA3DP by TMEM38A expression — LARGE_INTESTINE

Explore this box plot interactively →