TMEM38A

Across TCGA pan-cancer cohorts, TMEM38A Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TMEM38A data layer compared with 20 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher TMEM38A Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TMEM38A expression acts as an unfavorable survival marker.

COAD, LUSC, and LIHC are the cancer types where TMEM38A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	All	0.168	0.806	.002	24	view →
LUSC	DFS	Median	III,IV	0.235	0.638	.024	9	view →
LIHC	OS	Median	All	0.144	0.688	.013	9	view →
SKCM	DFS	Median	All	0.228	0.643	.005	9	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

TMEM38A–COAD (OS)

Open the COAD breakdown →