Q-omics provides the consensus-scored THEMIS profile across patient tissues and cancer cell-line models. THEMIS expression is associated with patient survival in 21 of 34 cancer types, with the highest sampling consensus in SKCM. Among the 18 cancer types available for tumor–normal comparison, THEMIS is differentially expressed in 7, with the highest sampling consensus in KIRC. Additionally, THEMIS RNA expression shows 17,905 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight SKCM, KIRC, and UVM as cancer lineages where THEMIS shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for THEMIS — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes THEMIS survival associations across molecular data types. THEMIS RNA expression shows survival associations in the most cancer types (21), followed by mutation status (9) and mass-spec protein abundance (4). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible THEMIS RNA expression–survival associations across cancer types. High THEMIS expression shows unfavorable associations in UVM, but favorable associations in SKCM, CESC, UCEC, BRCA and LUAD. The SKCM Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify SKCM as the clearest survival context for THEMIS RNA expression.
This table summarizes THEMIS tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 7, while mass-spec protein shows differences in 5. The strongest signals are observed in KIRC for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for THEMIS. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. THEMIS shows lower tumor expression in COAD, THCA, LUSC, LUAD and UCEC and higher tumor expression in KIRC. The KIRC box plot shows higher THEMIS RNA expression in tumor versus normal tissue (log2 FC = +1.392, t-test p < 0.001).
This table shows molecular features associated with THEMIS in patient tissues and cancer cell lines. In patient samples, THEMIS shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set. In cancer cell lines, THEMIS RNA and mutation anchors are most strongly linked to RNA-expression features, especially in UPPER_AERODIGESTIVE_TRACT, while CRISPR and shRNA rows add functional-dependency signals in BREAST and BLOOD_Leukemia.
