THEMIS

Across TCGA patient cohorts, THEMIS protein abundance is significantly associated with the RNA expression of many other genes, with 8,958 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible THEMIS-associated genes across cancer lineages are PRKCB, CCDC69, and PPP1R16B. Each is linked with THEMIS in more than 7 cancer types. Because this analysis shows association rather than direction, both THEMIS-to-partner and partner-to-THEMIS results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, THEMIS versus PRKCB in HNSC, with a Pearson correlation of 0.52.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THEMIS→partner) and Y-score (partner→THEMIS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PRKCB →	+0.977	+0.652	<.001	<.001	3	8
UCEC	CCDC69 →	+1.377	+0.704	<.001	.001	3	8
GBM	PPP1R16B →	+1.761	+0.795	<.001	<.001	3	7
GBM	TESPA1 →	+0.890	+0.606	<.001	.002	3	7
UCEC	TRGC1 →	+0.922	+0.783	.001	.001	3	7
LSCC	GRAP2 →	+0.779	+0.466	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,958 associations by consensus.

THEMIS vs PRKCB — HNSC

Explore this scatter interactively →