THEMIS

Across TCGA pan-cancer cohorts, THEMIS mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated THEMIS data layer compared with 21 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher THEMIS mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated THEMIS expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

PDAC, CCRCC, and LUAD are the cancer types where THEMIS mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	All	0.855	0.694	.002	41	view →
CCRCC	DFS	Quartile	All	1.000	0.581	.001	34	view →
LUAD	DFS	Median	All	0.755	0.510	.004	15	view →
UCEC	OS	Median	All	0.972	0.812	.016	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

THEMIS–PDAC (DFS)

Open the PDAC breakdown →