THEMIS

Across TCGA cell cohorts, THEMIS mutation is significantly associated with the RNA expression of many other genes, with 744 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible THEMIS-associated genes across cancer lineages are C5orf52, SPRR3, and TEX55. Each is linked with THEMIS in more than 1 cancer types. Because this analysis shows association rather than direction, both THEMIS-to-partner and partner-to-THEMIS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C5orf52 grouped by THEMIS-low versus THEMIS-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THEMIS→partner) and Y-score (partner→THEMIS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	C5orf52 →	+0.069	+5.643	<.001	.002	3	2
SOFT_TISSUE	SPRR3 →	+0.061	+4.930	<.001	.008	3	1
SOFT_TISSUE	TEX55 →	+0.026	+5.369	<.001	.004	3	1
SOFT_TISSUE	GP9 →	+0.026	+5.977	<.001	.001	3	1
SOFT_TISSUE	OR4X2 →	+0.032	+5.369	<.001	.004	3	1
SOFT_TISSUE	OR10K1 →	+0.006	+5.977	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 744 associations by consensus.

C5orf52 by THEMIS expression — LUNG_SCLC

Explore this box plot interactively →