THEMIS

Across TCGA cell cohorts, THEMIS RNA expression is significantly associated with the go_rna of many other GO terms, with 2,689 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible THEMIS-associated GO terms across cancer lineages are Regulation of centrosome duplication, Positive regulation of DNA biosynthetic process, and Nuclear division. Each is linked with THEMIS in more than 3 cancer types. Because this analysis shows association rather than direction, both THEMIS-to-partner and partner-to-THEMIS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of centrosome duplication grouped by THEMIS-low versus THEMIS-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (THEMIS→partner) and Y-score (partner→THEMIS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Regulation of centrosome duplication →	+0.099	+0.030	<.001	.007	3	4
BLOOD_Leukemia	Positive regulation of DNA biosynthetic process →	+0.047	+1.568	<.001	.002	3	4
OESOPHAGUS	Nuclear division →	+0.095	+0.030	.003	.007	3	4
OESOPHAGUS	Microtubule organizing center organization →	+0.118	+0.041	<.001	.004	3	4
BLOOD_Leukemia	Microtubule anchoring →	+0.056	+1.735	<.001	<.001	3	4
BLOOD_Leukemia	Negative regulation of peroxisome proliferator activated receptor signaling pathway →	+0.087	+1.785	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,689 associations by consensus.

Regulation of centrosome duplication by THEMIS expression — OESOPHAGUS

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