Q-omics provides the consensus-scored THAP1 profile across patient tissues and cancer cell-line models. THAP1 expression is associated with patient survival in 25 of 34 cancer types, with the highest sampling consensus in CESC. Among the 18 cancer types available for tumor–normal comparison, THAP1 is differentially expressed in 12, with the highest sampling consensus in HNSC. Additionally, THAP1 RNA expression shows 19,682 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight CESC, HNSC, and ACC as cancer lineages where THAP1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for THAP1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes THAP1 survival associations across molecular data types. THAP1 RNA expression shows survival associations in the most cancer types (25), followed by mutation status (4). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible THAP1 RNA expression–survival associations across cancer types. High THAP1 expression shows unfavorable associations in CESC, KIRP, KICH, SCLC and STAD, but favorable associations in KIRC. The CESC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .003). Together, the overview and detailed table identify CESC as the clearest survival context for THAP1 RNA expression.
This table summarizes THAP1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 12. The strongest signals are observed in HNSC for RNA.
This table ranks reproducible tumor–normal expression differences for THAP1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. THAP1 shows lower tumor expression in THCA and KICH and higher tumor expression in HNSC, LIHC, BRCA and CHOL. The HNSC box plot shows higher THAP1 RNA expression in tumor versus normal tissue (log2 FC = +0.790, t-test p < 0.001).
This table shows molecular features associated with THAP1 in patient tissues and cancer cell lines. In patient samples, THAP1 shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set. In cancer cell lines, THAP1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in BONE, while CRISPR and shRNA rows add functional-dependency signals in UPPER_AERODIGESTIVE_TRACT and LARGE_INTESTINE.
