THAP1

Across TCGA cell cohorts, THAP1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,754 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible THAP1-associated GO terms across cancer lineages are Interkinetic nuclear migration, Regulation of regulatory ncRNA-mediated heterochromatin formation, and Negative regulation of regulatory ncRNA-mediated heterochromatin formation. Each is linked with THAP1 in more than 16 cancer types. Because this analysis shows association rather than direction, both THAP1-to-partner and partner-to-THAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Interkinetic nuclear migration grouped by THAP1-low versus THAP1-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (THAP1→partner) and Y-score (partner→THAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Interkinetic nuclear migration →	+0.138	+0.944	<.001	<.001	3	17
STOMACH	Regulation of regulatory ncRNA-mediated heterochromatin formation →	+0.110	+0.441	<.001	<.001	3	12
STOMACH	Negative regulation of regulatory ncRNA-mediated heterochromatin formation →	+0.110	+0.441	<.001	<.001	3	12
LUNG_SCLC	Protein localization to chromosome →	+0.064	+0.288	<.001	.004	3	12
BREAST	Negative regulation of heterochromatin organization →	+0.091	+0.708	<.001	<.001	3	11
BREAST	Negative regulation of heterochromatin formation →	+0.091	+0.708	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,754 associations by consensus.

Interkinetic nuclear migration by THAP1 expression — URINARY_TRACT

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