THAP1

Across TCGA patient cohorts, THAP1 protein abundance is significantly associated with the RNA expression of many other genes, with 692 significant associations in total. GBM shows the largest number of these associations.

The most reproducible THAP1-associated genes across cancer lineages are SPTLC2, DICER1, and RNF125. Each is linked with THAP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both THAP1-to-partner and partner-to-THAP1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, THAP1 versus SPTLC2 in GBM, with a Pearson correlation of 0.61.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THAP1→partner) and Y-score (partner→THAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SPTLC2 →	+0.951	+1.143	.002	<.001	3	1
GBM	DICER1 →	+0.875	+1.078	.003	.003	3	1
GBM	RNF125 →	+0.878	+1.055	<.001	<.001	3	1
GBM	SHOC2 →	+0.509	+0.965	.001	<.001	3	1
GBM	TBC1D12 →	+0.882	+0.896	<.001	.002	3	1
GBM	ASPA →	+1.694	+0.953	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 692 associations by consensus.

THAP1 vs SPTLC2 — GBM

Explore this scatter interactively →