ring finger protein 125Genealiases: TNORS · TRAC-1 · TRAC1
Q-omics provides the consensus-scored RNF125 profile across patient tissues and cancer cell-line models. RNF125 expression is associated with patient survival in 26 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, RNF125 is differentially expressed in 16, with the highest sampling consensus in KIRC. Additionally, RNF125 RNA expression shows 19,257 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight KIRC, and UVM as cancer lineages where RNF125 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for RNF125 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes RNF125 survival associations across molecular data types. RNF125 RNA expression shows survival associations in the most cancer types (26), followed by mutation status (2) and mass-spec protein abundance (1). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible RNF125 RNA expression–survival associations across cancer types. High RNF125 expression shows unfavorable associations in UVM, but favorable associations in KIRC, BRCA, HNSC, LIHC and SARC. The KIRC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for RNF125 RNA expression.
This table summarizes RNF125 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 16, while mass-spec protein shows differences in 1. The strongest signals are observed in KIRC for RNA and LUAD for protein.
This table ranks reproducible tumor–normal expression differences for RNF125. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. RNF125 shows lower tumor expression in COAD, LUSC, KICH, LIHC and HNSC and higher tumor expression in KIRC. The KIRC box plot shows higher RNF125 RNA expression in tumor versus normal tissue (log2 FC = +0.847, t-test p < 0.001).
This table shows molecular features associated with RNF125 in patient tissues and cancer cell lines. In patient samples, RNF125 shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set. In cancer cell lines, RNF125 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in CNS, while CRISPR and shRNA rows add functional-dependency signals in LARGE_INTESTINE and SKIN.
