RNF125

Across TCGA pan-cancer cohorts, RNF125 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated RNF125 data layer compared with 2 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher RNF125 RNA is associated with better overall survival. In most high-consensus cancer types, elevated RNF125 expression acts as an unfavorable survival marker, although some lineages such as KIRC and BRCA show a favorable association.

KIRC, UVM, and BRCA are the cancer types where RNF125 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	All	0.750	0.548	<.001	123	view →
UVM	DFS	Median	All	0.420	0.773	<.001	122	view →
BRCA	OS	Quartile	III,IV	0.901	0.698	<.001	66	view →
HNSC	DFS	Median	IV	0.713	0.567	.005	40	view →
LIHC	OS	Tertile	All	0.836	0.693	.002	33	view →
SARC	OS	Median	All	0.817	0.672	.001	27	view →
STAD	DFS	Quartile	All	0.594	0.821	.023	21	view →
LUAD	DFS	Median	All	0.752	0.608	.010	19	view →
ACC	OS	Median	All	0.737	0.454	.009	15	view →
DLBC	DFS	Median	All	0.629	0.915	.012	13	view →
CHOL	DFS	Quartile	All	1.000	0.115	.001	12	view →
LGG	OS	Tertile	All	0.819	0.939	.005	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

RNF125–KIRC (OS)

Open the KIRC breakdown →