THAP1

Across TCGA patient cohorts, THAP1 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,165 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible THAP1-associated GO terms across cancer lineages are Translesion synthesis, mRNA alternative polyadenylation, and Interkinetic nuclear migration. Each is linked with THAP1 in more than 31 cancer types. Because this analysis shows association rather than direction, both THAP1-to-partner and partner-to-THAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Translesion synthesis grouped by THAP1-low versus THAP1-high in THYM.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (THAP1→partner) and Y-score (partner→THAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THYM	Translesion synthesis →	+0.057	+0.543	<.001	<.001	3	32
UVM	mRNA alternative polyadenylation →	+0.072	+0.951	<.001	<.001	3	31
SCLC	Interkinetic nuclear migration →	+0.125	+0.447	<.001	<.001	3	31
ESCA	Interstrand cross-link repair →	+0.071	+0.397	<.001	<.001	3	31
SCLC	Error-prone translesion synthesis →	+0.098	+0.351	<.001	.002	3	31
DLBC	Neuronal stem cell population maintenance →	+0.060	+0.501	.001	.002	3	30

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,165 associations by consensus.

Translesion synthesis by THAP1 expression — THYM

Explore this box plot interactively →