THAP1

Across TCGA patient cohorts, THAP1 mutation is significantly associated with the RNA expression of many other genes, with 1,832 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible THAP1-associated genes across cancer lineages are RNU6-1155P, RNU6-220P, and RN7SL849P. Each is linked with THAP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both THAP1-to-partner and partner-to-THAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1155P grouped by THAP1-low versus THAP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THAP1→partner) and Y-score (partner→THAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-1155P →	+0.122	+4.475	.002	.003	3	2
BRCA	RNU6-220P →	+0.583	+5.721	<.001	.003	3	2
BRCA	RN7SL849P →	+0.257	+5.317	<.001	.006	3	2
UCEC	POM121C →	+0.556	+3.364	<.001	.004	3	1
UCEC	DCP1A →	+0.691	+3.700	.001	.001	3	1
UCEC	ZNHIT3 →	+0.604	+3.721	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,832 associations by consensus.

RNU6-1155P by THAP1 expression — UCEC

Explore this box plot interactively →