THAP1

Across TCGA patient cohorts, THAP1 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible THAP1-associated genes across cancer lineages are eIF4E, FOXO3a_pS318_S321, and GSK-3_pS9. Each is linked with THAP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both THAP1-to-partner and partner-to-THAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by THAP1-low versus THAP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THAP1→partner) and Y-score (partner→THAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.216	+2.321	.041	.035	3	1
UCEC	FOXO3a_pS318_S321 →	-0.153	-3.160	.014	.019	3	1
UCEC	GSK-3_pS9 →	-0.605	-3.321	.002	.010	3	1
UCEC	JNK_pT183_Y185 →	-0.190	-3.169	.025	.019	3	1
UCEC	MEK1 →	+0.483	+3.169	.008	.019	3	1
UCEC	Notch1 →	+0.235	+3.009	<.001	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

eIF4E by THAP1 expression — UCEC

Explore this box plot interactively →